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That's about the size of my 2 channel space (converted 3rd car garage, treated, etc.).
I have S2's and I find them plenty for my room, though am using it for music only.
Not sure what the definition of mid-bass slam is, but I found that I had to set my sub crossover to 50 hz. to keep the Sierras from competing with the sub in the mid-bass area.
I listened to everything except the Horizons when I made my decision, and if I had the $$ would have gone with the towers.
Personally, from what I know of the Horizon I think you'd be fine with the S2s and have more $$ to put into a better sub, which I think would make a bigger difference for HT.
With the current offer of free returns, you could always give the S2s a shot and upgrade if you really think you need to.