Welcome Adam. I recently lost my sister to stage 4 lung cancer, and have a similar set up to yours.

Sierra 2's and a 12" Rythmik Sub. I'm fortunate to have a corrected listening space, which makes it all so nice.

As to placement, Isoacoustics, etc., I find the set up works very very well in near field mode and a more traditional (8 foot removed) placement.

I have my Sierra's adjacent to my work surface, and enjoy them at low volume and close in, as well as a bit more dBs at a distance. The detail on the Sierra 2's can be appreciated from any distance!

As Dave said, pick your genre for the evening, and let it all go. A beverage of your choosing never hurts as well!